September 23, 2025
Transgenic Models to Study Angiogenesis and Lymphangiogenesis: An Historical Note
Key Points
- Transgenic models provide crucial insights into mechanisms regulating angiogenesis and lymphangiogenesis.
- Knockout mice have been significant in determining gene functions during embryonic development and homeostasis.
- This review summarizes the evolution of transgenic technology in studying vascular biology.
- Investigating genetic alterations illuminates their impacts on critical developmental processes.
Abstract
ABSTRACT The knockout mouse has been a valuable tool for geneticists to discern the role of a gene in embryonic development and in normal physiological homeostasis. The development of transgenic technologies in mice has allowed the study of the consequences of genetic alterations on angiogenesis and lymphangiogenesis. This historical review article summarizes the first literature evidence concerning the use of transgenic models to study the most important factors involved in the regulation of angiogenesis and lymphangiogenesis.
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Authors
Doménico Ribatti
University of Siena
Journals
Clinical Anatomy
Actions
Institutions
University of Bari Aldo Moro
References and Citations
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