Metallic nanoclusters (NCs), composed of a few to a hundred atoms, occupy a unique space between molecules and nanoparticles, exhibiting discrete electronic states, strong photoluminescence, and size-dependent catalytic activity. Their ultrasmall cores (<3 nm) and ligand-controlled surfaces confer tunable optical, electronic, and catalytic properties, making them attractive for diverse applications. In recent years, significant progress has been made toward developing faster, more reproducible, and scalable synthesis routes beyond classical wet-chemical reduction. Emerging strategies such as microwave-, photochemical-, sonochemical-, and catalytically assisted syntheses, together with smart, automation-driven platforms, have improved efficiency, structural control, and environmental compatibility. These advances have accelerated the deployment of NCs in imaging, sensing, and catalysis. Near-infrared emitting NCs enable deep-tissue, high-contrast fluorescence imaging, while theranostic platforms combine diagnostic precision with photothermal or photodynamic therapy, gene delivery, and anti-inflammatory treatment. NC-based sensors allow ultrasensitive detection of ions, small molecules, and pathogens, and atomically precise NCs have enabled efficient CO2 reduction, water splitting, and nitrogen fixation. Therefore, in this review, we highlight studies reported in the past five years on the synthesis and applications of metallic NCs, linking emerging methodologies to their functional potential in nanotechnology.
Hada et al. (Tue,) studied this question.