Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 23, 2025MetabolitesOpen Access

Hexavalent Chromium Induces Defense Responses, Hepatocellular Apoptosis, and Lipid Metabolism Alterations in New Zealand Rabbit Livers

View Full Paper
Ask AI
Bookmark
Share

Authors

JYJunzhao YuanLZLei ZhangXLXiuqing Li

Discussion

Loading...

Member takes

Overview

Experimental analysis revealed hexavalent chromium alters lipid metabolism and triggers hepatocellular apoptosis in rabbits, indicating potential health risks.

Key Points

  • Hexavalent chromium exposure leads to significant hepatic injury and apoptosis in New Zealand rabbits.
  • All treatment groups showed elevated antioxidant gene expression, indicating activated defense mechanisms.
  • Exposure to chromium disrupted lipid metabolism, shown by increased fat deposition in liver tissues.
  • Notable decreases in essential trace elements were observed, with alterations in copper levels based on dosage.

Cite This Study

Yuan et al. (2025) studied this question.

synapsesocial.com/papers/68d4759931b076d99fa6db0chttps://doi.org/10.3390/metabo15100637
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic Mechanisms of Hexavalent Chromium-Induced Splenic Immune Injury via Oxidative Stress and Ferroptosis Pathways in New Zealand Rabbits2026
  2. 2Chronic low‐dose chromium VI exposure induces oxidative stress and apoptosis with altered expressions of DNA repair genes and promoter hypermethylation in the liver of Swiss albino mice2024 · 9 citations
  3. 3Subchronic Exposure to Hexavalent Chromium in Drinking-Water-Induced Sex-Dependent Essential Metal Dyshomeostasis in the Liver, Blood, and Brain of Guinea Pigs2026
  4. 4Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway2024 · 2 citations
  5. 5Analyzing the Biochemical Alterations and Histopathological changes in Oxidative Stress-Induced Tissue Damage. A Study on Antioxidant Therapeutic Interventions2023