Clinical case highlights complex interaction of long-covid and immunodeficiency, suggesting urgency in treatment.
The COVID-19 pandemic has led to global consequences, including Long-COVID. This term is used to refer to the symptoms of a new coronavirus infection that last more than 4 weeks, but less than 12 weeks from the onset of the disease. The most common symptoms are shortness of breath, cough, and general weakness. The risk group for the long-term course of COVID-19 includes patients with immunodeficiency. One of the reasons for the long-term persistence of symptoms is the persistence of the virus in the body. However, in 30–40% of cases, the results of the SARS-CoV-2 test turn out to be negative, which makes it difficult to make a diagnosis. In addition, patients with immunodeficiency against Long-COVID may develop opportunistic infections caused by reactivated opportunistic microflora against the background of lymphopenia. The presented clinical example demonstrates a case of Long-COVID infection complicated by the development of pneumocystis pneumonia in a patient with follicular lymphoma. Timely diagnosis and initiation of specific treatment made it possible to stabilize the patient’s condition and prevent the fulminant course of pneumocystis infection.
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Demina et al. (2025) studied this question.
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