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September 23, 2025VirusesOpen Access

Molecular Insights into HPV-Driven Head and Neck Cancers: From Viral Oncoproteins to Precision Therapeutics

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HPV-driven head and neck cancers demonstrate improved prognosis and treatment responses, indicating a need for therapy de-escalation.
Oncogenic E6 and E7 proteins are critical to how HPV disrupts tumor suppressor pathways, affecting cancer progression.
Strategies like immune checkpoint inhibitors and CRISPR gene editing are advancing precision oncology in HPV-related cancers.
Preventive HPV vaccination shows promise, necessitating further research into its efficacy across various head and neck cancer subtypes.

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This review explores HPV's role in head and neck cancers, highlighting oncogenic mechanisms and precision therapeutic strategies.

Özdoğan et al. (2025) studied this question.

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