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September 23, 2025GeneticsOpen Access

A forest is more than its trees: haplotypes and ancestral recombination graphs

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Authors

HFHalley FritzeNPNathaniel S. PopeJKJerome Kelleher

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Overview

Analysis reveals how non-coalescing haplotypes enhance ancestral recombination graphs, suggesting improved accuracy in genealogical studies.

Key Points

  • Incorporating non-coalescing haplotypes into ancestral recombination graphs results in more compact structures.
  • The study introduces algorithms that efficiently infer locally-unary nodes within existing ancestral recombination graphs.
  • New metrics are developed to evaluate agreement between ancestral recombination graphs and haplotypes.
  • The findings highlight the potential for improved accuracy in reconstructing genealogical relationships among sequences.

Cite This Study

Fritze et al. (2025) studied this question.

synapsesocial.com/papers/68d475a031b076d99fa6df06https://doi.org/10.1093/genetics/iyaf198
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