⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

September 23, 2025Synfacts

Dinuclear Copper-Catalyzed Enantioselective [3+2] Annulation to Access Cyclic Quaternary Stereocenters

View Full Paper

Ask AI

Bookmark

Share

Key Points

The synthesis achieved enantioselective [3+2] annulation to create cyclic quaternary stereocenters effectively.
The method exhibits significant efficiency with dinuclear copper catalysis, providing enhanced reaction control.
Utilizing propargylic substitution, the approach expands the toolkit for constructing complex cyclic molecules.
This technique may enable the development of new synthetic routes in organic chemistry, enhancing molecular diversity.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

This method demonstrates high enantioselectivity in accessing cyclic structures, suggesting new applications in synthetic chemistry.

Abstract

Keywords dinuclear copper catalysis - propargylic substitution - [3+2] annulation

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68d4764731b076d99fa6dff8 https://doi.org/10.1055/a-2680-9004

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Copper-Catalyzed Enantioconvergent Propargylic Amination to Access Chiral α-Tertiary Amines2024
2Asymmetric Dearomatization of Nonfunctionalized 1-Naphthols via Copper-Catalyzed Enantioselective [4 + 1] Spiroannulation2024 · 38 citations
3Mechanisms, Regio-and Stereoselectivities for NHC-Catalyzed [3+3] Annulations for the Synthesis of Axially and Centrally Chiral Dihydropyridinones2025
4The Copper‐Catalyzed [4 + 1] Annulation of Ethynyl Methylene Cyclic Carbamates With Various Activated Methylene Compounds to Construct Spiro‐Cyclopentane Derivatives2025 · 1 citations
5Synthesis of 2,3-Diaroylquinolines via Copper-Catalyzed [4+1+1] Annulation2024