Validation reveals BrainTRACE accurately localizes ECoG grids in brain tumor patients, suggesting its clinical utility in neurosurgical settings.
BrainTRACE is a freely available, MATLAB-based workflow for localizing intraoperative electrocorticography (ECoG) subdural grids in patients with brain tumors when post-operative imaging is impractical. The tool fuses pre-operative T1-weighted MRI, cortical vascular reconstructions, and intraoperative photographs to place electrode arrays on patient-specific 3D cortical surfaces. Its GUI supports anatomical/vascular landmark–guided grid initialization, optional import of neuronavigation fiducials, alignment of “grid-on/off” photos, manual per-contact refinement, and BIDS-compliant coordinate export. In validation across tumor cases, expert raters achieved high inter-rater reliability (ICC ≈ 0.93) with mean deviations of ~4 mm from consensus, while novice variability underscores the need for neuroanatomical context. BrainTRACE enables accurate, photograph-guided intraoperative localization to support clinical mapping and research in oncology and epilepsy, using imaging routinely available in neurosurgical workflows.
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Oten et al. (2024) studied this question.
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