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This is a Experimental Study study.

September 12, 2025Folia Biologica

Preventive Effect of Indomethacin and Melatonin on 7,12-dimethylbenz/a/anthracene-Induced Mammary Carcinogenesis in Female Sprague-Dawley Rats. A Preliminary Report

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Experimental analysis reports indomethacin and melatonin reduce tumor incidence in female rats, suggesting potential for chemoprevention.

Indomethacin significantly reduced tumour incidence to 36.84%, while melatonin reduced it to 42.11%.
In a 26-week experiment, the combination of indomethacin and melatonin showed a favourable chemopreventive effect.
Chemoprevention began 10 days before administering the carcinogen DMBA to assess oncostatic effects effectively.
Indomethacin and melatonin together did not affect tumour volume but were effective in decreasing malondialdehyde levels.

Môciková-Kalická et al. (2001) studied this question.

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