The study explores how histone acetyltransferase and histone deacetylase regulate gene expression, indicating potential therapeutic avenues.
The epigenetic modification is necessary to decondense the DNA in the transcription region so that the further transcription process can proceeds. Acetylation by HAT causes the activation of the transcription and deacetylation by HDAC causes the deactivation of the transcription process. So, the epigenetic modification can act as a switch to turn on and turn off the transcription. Gene regulation can be control by this switching mechanism. The imbalance in acetylation and deacetylation can leads to several disorders which cause many diseases such as cancer, tumours, cardiological and vascular disease, neurological disease. HAT and HDAC inhibitors are now being utilised in clinical research and medication development
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Khatun et al. (2021) studied this question.
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