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September 24, 2025Critical Care ExplorationsOpen Access

Detecting Pain Correlates With Recovery in Acute Brain Injury Patients With Disorders of Consciousness

Julia Houshmand Brian Manolovitz Kelsey E. Ladd Danielle Bass Elena Mishkovsky Ana Bolaños Saavedra Fernanda J.P. Teixeira David Monroy Esther Monexe Tulay Koru‐Sengul Linda E. Robayo Kristiina Kinnunen Lee K. Hong John A McKeown Nina Massad Mohan Kottapally Amedeo Merenda Kristine O’Phelan Ayham Alkhachroum

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Key Points

Higher levels of pain correlate with improved recovery outcomes in patients with acute brain injury.
Patients who experienced moderate to severe pain had significantly higher odds of consciousness recovery at 12 months.
The study analyzed correlations between pain levels and Glasgow Outcome Scale-Extended scores over multiple time points.
Pain levels were assessed using the critical care pain observation tool in a prospective observational study.

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Implication

Prospective study links pain levels to improved recovery in brain injury patients, suggesting pain as a recovery biomarker.

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Cite This Study

Houshmand et al. (2025) studied this question.

synapsesocial.com/papers/68d6c671b1249cec298b20f8 https://doi.org/10.1097/cce.0000000000001323

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