Effects of Photobiomodulation Adjunct Therapy via Superpulsed 904 nm Laser in Patients With Second‐Degree Burns: Randomized Controlled Clinical Trial

Photobiomodulation therapy (PBMT) using near‐infrared (NIR) light offers a non‐invasive healing approach with deep‐tissue penetration that enhances cellular proliferation, mitochondrial bioenergetics, reduces inflammation, and restores functions. However, clinical evidence for NIR‐PBMT in burn care remains limited. This randomized, active‐controlled trial evaluated the effects of 904 nm superpulsed laser NIR‐PBMT as an adjunct to standard care (SOC; 1% silver‐sulfadiazine, paraffin‐gauze) for second‐degree burn patients. Participants received either sham‐exposed ( n = 12) or 904 nm‐PBMT ( n = 12; 100 Hz frequency, 200‐ns pulse width, 10 min, 1.1 J/session, twice weekly). The study evaluated re‐epithelialization time, wound reduction, pain intensity (VAS score), blood PCT/CRP levels, and microbial load. NIR‐PBMT significantly ( p < 0.05) accelerated healing, re‐epithelialization (8.3 vs. 12.6 days), wound reduction, granulation tissue formation, and decreased pain compared to sham‐exposed. Neither group showed evidence of microbial infection or changes in PCT/CRP levels. These findings indicate that NIR‐PBMT is an effective non‐invasive adjunct therapy for faster repair of second‐degree burns. Further, large‐scale trials are needed.