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This is a Experimental Study study.

September 26, 2025The CRISPR JournalOpen Access

Efficient Installation of Heterozygous Mutations in Human Pluripotent Stem Cells Using Prime Editing

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Prime editing achieves up to 40% efficiency for heterozygous edits in hPSCs, highlighting benefits over traditional gene editing methods.

Prime editing can achieve up to 40% efficiency for heterozygous mutations in human pluripotent stem cells.
The method enables precise edits in over 10 genetic loci, demonstrating its broad applicability.
Combining prime editing with reprogramming allows for deriving heterozygous stem cell clones from various sources.
This approach supports modeling disease-associated mutations in a fully isogenic context.

Suter et al. (2025) studied this question.

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