Exploiting Supercooled Medium-Chain Lipids and Surfactant Combinations for Solid-Phase Dominant Nanostructured Lipid Carrier Production

Daniel Sedough-Abbasian; Jiaming Mu; Jerin Joseph; Gavin P. Andrews; Sheiliza Carmali

doi:10.1039/d5tb00676g

January 1, 2025Journal of Materials Chemistry BOpen Access

Exploiting Supercooled Medium-Chain Lipids and Surfactant Combinations for Solid-Phase Dominant Nanostructured Lipid Carrier Production

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Key Points

Unpredictable drug partitioning between solid and liquid lipid phases complicates NLCs’ effectiveness.
Supercooled medium-chain lipids improve the solid-phase characteristics and stability of NLCs.
Surfactant combinations play a critical role in optimizing the performance of nanostructured lipid carriers.
Effective delivery of lipophilic peptides using NLCs can enhance therapeutic outcomes in drug delivery systems.

Implication

Analysis reveals effects of surfactant combinations on solid-phase properties in NLCs, highlighting unpredictable drug partitioning.

Abstract

Nanostructured lipid carriers (NLCs) are a promising delivery system for poorly water-soluble drugs, including lipophilic peptides. However, NLCs often display unpredictable drug partitioning between solid and liquid lipid phases, potentially...

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Cite This Study

Sedough-Abbasian et al. (2025) studied this question.

synapsesocial.com/papers/68d6c67db1249cec298b23a7 https://doi.org/10.1039/d5tb00676g

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Exploiting Supercooled Medium-Chain Lipids and Surfactant Combinations for Solid-Phase Dominant Nanostructured Lipid Carrier Production

Key Points

Implication

Abstract

Discussion

Cite This Study

Exploiting Supercooled Medium-Chain Lipids and Surfactant Combinations for Solid-Phase Dominant Nanostructured Lipid Carrier Production

Key Points

Implication

Abstract

Discussion

Cite This Study

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