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September 26, 2025IUBMB Life

Exploring Macrophage Contribution to Vascular Calcification in Atherosclerosis

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This review highlights macrophage roles in vascular calcification processes in atherosclerosis, suggesting therapeutic targets.

Macrophages play a crucial role in vascular calcification associated with atherosclerosis, influencing morbidity outcomes.
Pro-inflammatory M1 macrophages secrete cytokines that promote vascular smooth muscle cell calcification through various pathways.
M2 macrophages exhibit functions that potentially protect against excessive vascular calcification in atherosclerotic plaques.
The balance of macrophage populations affects calcification dynamics, and targeting these may lead to improved cardiovascular health.

Dabravolski et al. (2025) studied this question.

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