PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
September 26, 2025Circulation Heart Failure

Unraveling the Pathophysiological Mechanisms of Phospholamban R14del Cardiomyopathy: A Comprehensive Overview

View Full Paper
Ask AI
Bookmark
Share

Authors

RMRenée G. C. MaasLKLuuk KerckhaertJBJudy Broersma

Discussion

Loading...

Member takes

Overview

This comprehensive review highlights the PLN-R14del mutation's role in cardiomyopathy, indicating critical physiological disruptions.

Key Points

  • PLN-R14del mutation significantly contributes to dilated and arrhythmogenic cardiomyopathy, raising transplant needs.
  • Numerous cases of PLN-R14del have been documented globally, emphasizing its impact on heart disease prevalence.
  • Extensive literature shows PLN's role in calcium regulation, yet its exact pathophysiological mechanisms remain debated.
  • Future research is essential for developing targeted diagnoses and treatments for PLN-R14del–affected individuals.

Cite This Study

Maas et al. (2025) studied this question.

synapsesocial.com/papers/68d6cd5bb1249cec298b317ehttps://doi.org/10.1161/circheartfailure.124.012661
View Full Paper
Ask AI
Bookmark
Share