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March 6, 2025Netherlands Heart JournalOpen Access

Identification of disease-specific pathways and modifiers in phospholamban R14del cardiomyopathy: rationale, design and baseline characteristics of DECIPHER-PLN cohort

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Why the study?

Many characteristics of PLN R14del cardiomyopathy remain unclear, including phenotypic triggers, disease progression, and disease-specific biomarkers.

Population

101 participants, including 91 PLN R14del carriers and 10 with HF of another aetiology

Comparison

Unaffected vs early affected vs end-stage PLN R14del carriers vs HF of another aetiology

Design

Cohort study rationale, design, and baseline characteristics

Authors

FDFrederik E. DeimanRBRemco de BrouwerLBLukas Baumhove

Discussion

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Overview

New PLN R14del cohort spans disease spectrum; leaves open triggers, progression, and biomarkers for future study.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Deiman et al. (2025) studied this question.

synapsesocial.com/papers/6a728475b27f158178280f96https://doi.org/10.1007/s12471-025-01941-8
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