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This is a Experimental Study study.

Methylation and Alkylation of Pyridines at the meta Position Using Aldehydes or Aldehyde Surrogates

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Meta-methylation of pyridines enables selective synthesis of diverse compounds, enhancing drug potency.
The method shows excellent selectivity for monomethylation, producing a wide range of meta-methyl-substituted pyridines.
Utilizing aldehydes allows for meta-alkylation, broadening the therapeutic applications of the synthesized pyridines.
Mechanistic studies support the essential role of the borane catalyst, indicating potential for further optimization.

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Novel meta-C–H methylation and alkylation techniques on pyridines using aldehydes, suggesting enhanced drug potential.

Chen et al. (2025) studied this question.

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