This research demonstrates selective C2-alkylation of pyridine, highlighting its potential in improving drug-like properties.
Pyridine is a privileged scaffold in pharmaceuticals, and selective C2-alkylation, particularly methylation, represents a valu-able strategy to fine-tune drug-like properties such as metabolic stability and solubility. However, achieving highly site-selective...
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Fu et al. (2026) studied this question.
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