Regioselective one-step C2–H methylation of free (N–H) indoles enabled by Pd(II)/norbornene cooperative catalysis

Yutong Sun; Wenlin Zhang; Yangang Liu; Zhixin Zhang; Mengyao Hu; Margaret Liu; Hong‐Bo Qin; Helin Lu

doi:10.1039/d5qo00869g

January 1, 2025Organic Chemistry Frontiers

Regioselective one-step C2–H methylation of free (N–H) indoles enabled by Pd(II)/norbornene cooperative catalysis

View at Publisher

Ask AI

Bookmark

Share

Key Points

C2–H methylation achieved in a single step, streamlining traditional multi-step synthesis.
The method employs Pd(II)/norbornene cooperative catalysis to selectively modify indoles.
This approach could significantly reduce time and resources in creating pharmaceutical compounds.
Indolic compounds are essential in many biologically active molecules, highlighting the importance of efficient synthesis.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

One-step C2–H methylation improves synthesis of indole compounds, suggesting enhanced efficiency in pharmaceutical development.

Abstract

The C2-methylated indole scaffolds are prevalent and crucial components of numerous pharmaceutical molecules and biologically active entities. However, its synthesis traditionally requires a laborious three-step sequence involving the installation of...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68a36de60a429f79733317b6 https://doi.org/10.1039/d5qo00869g

View at Publisher

Ask AI

Bookmark

Share

Regioselective one-step C2–H methylation of free (N–H) indoles enabled by Pd(II)/norbornene cooperative catalysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Regioselective one-step C2–H methylation of free (N–H) indoles enabled by Pd(II)/norbornene cooperative catalysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading