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December 9, 2025Advanced Synthesis & Catalysis

Hydricity Modulated Methylation of Indoles and Nitriles Using Methanol: Selective Synthesis of C3‐Methylated Indoles, Bisindolylmethanes, and α‐Methylated Nitriles

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Authors

MPManoj PradhanIndian Institute of Technology KanpurAMAdarsha MandalIndian Institute of Technology KanpurPTPushpendra TiwariIndian Institute of Technology BHU

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Overview

Functionalization of indoles with methanol demonstrates varied product selectivity, indicating the role of hydricity and electronic properties.

Key Points

  • This research aims to explore selective methylation of indoles using methanol through borrowing hydrogen pathways.
  • Synthesis of cyclometalated Ru(II) complexes
  • Application in chemodivergent functionalization of indoles
  • Study of electronic properties via electrochemical and density functional theory analyses
  • Control experiments to identify intermediates
  • Selective formation of C3-methylated indoles and bisindolylmethanes under varying conditions
  • Hydricity of Ru–H species was tuned by ligand modifications
  • Electron-rich NC-Ru complex achieved α-methylation of phenylacetonitrile

Cite This Study

Pradhan et al. (2025) studied this question.

synapsesocial.com/papers/69401d622d562116f28f8fa2https://doi.org/10.1002/adsc.70224
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