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November 28, 2025ChemCatChem

A Versatile Ru‐Catalyst for Selective Methylation of Diverse Organic Scaffolds Using Methanol as a C1 Synthon

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Authors

SSSubhangi SahaSCSantana ChakrabortyADArjun Datta

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Overview

Ru-catalyzed methylation improves reactivity across diverse organic scaffolds, suggesting a versatile single-catalyst approach.

Key Points

  • Methylation using methanol achieved high efficiency across multiple organic scaffolds, and exhibits low base loading.
  • An exceptional Ru(III)‐catalyst was developed, featuring a triamine ligand for enhanced reactivity and compatibility.
  • Mechanistic pathways include dehydrogenation, condensation, and borrowing-hydrogenation, enabling diverse substrate reactions.
  • This single-catalyst approach may eliminate the need for multiple catalysts, simplifying synthetic methodologies under mild conditions.

Cite This Study

Saha et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a27dhttps://doi.org/10.1002/cctc.202501458
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