Highly Regioselective Hydroaminomethylation for Amine Synthesis Enabled by a Heterogeneous Molecular Catalyst Ru ₃ /QDPOP

In this work, we report an efficient protocol for direct amine synthesis from alkenes catalyzed by a heterogeneous molecular catalyst Ru₃/QDPOP, which features well-defined trinuclear Rh centers stabilized by a phosphine-functionalized porous organic polymer. The catalyst exhibited high activity and excellent regioselectivity toward the desired linear amines, significantly surpassing previously reported homo- and heterogeneous Ru-based catalysts. Various secondary and tertiary amines, including pharmaceutically relevant compounds, can be effectively synthesized from diverse amines and alkenes under mild conditions. Moreover, the catalyst is stable and recyclable, maintaining high performance over five cycles without appreciable loss in performance.