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July 8, 2026Advanced Synthesis & Catalysis

Ru(II)‐Catalyzed C3‐H Functionalization of Indoles With Isatogens

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Authors

CHChaitra Narayan HegdeNational Chemical LaboratoryTRThayalan RajeshkumarCentre National de la Recherche ScientifiqueLMLaurent MaronCentre National de la Recherche Scientifique

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Overview

Randomized trial demonstrates effective synthesis of indole-derived compounds, suggesting a new methodology for producing valuable natural products.

Key Points

  • The central aim is to develop a simple methodology for synthesizing the 2-(1H-indol-3-yl)indolin-3-one core found in various natural products.
  • Ru(II)-catalyzed regioselective addition of indoles to isatogens was implemented.
  • Control experiments and density functional theory calculations were conducted to investigate the mechanism.
  • The method yielded a range of C2-indolyl indolin-3-one compounds.
  • A variety of indolin-3-one compounds were synthesized with good yields.
  • The synthesis includes natural products halichrome A and metagenediindole A.
  • A mechanism involving a bimetallic Ru complex was proposed based on experimental findings.

Cite This Study

Hegde et al. (2026) studied this question.

synapsesocial.com/papers/6a4dea63d2ea289ef6284154https://doi.org/10.1002/adsc.70625
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