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Demonstrates effective synthesis of indole-derived compounds, suggesting a new methodology for producing valuable natural products.
A simple methodology for the synthesis of the 2‐(1 H ‐indol‐3‐yl)indolin‐3‐one core present in various natural products is developed. This method comprises Ru(II)‐catalyzed regioselective addition of indole to isatogen, along with N─O bond reduction. A range of indolin‐3‐one compounds incorporating a C2‐indolyl unit are synthesized under catalytic conditions in good yields, including the natural products halichrome A and metagenediindole A. With the help of control experiments and density functional theory calculations, a plausible mechanism founded upon the involvement of a bimetallic Ru complex is proposed.
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Hegde et al. (2026) studied this question.
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