January 1, 2025RSC AdvancesOpen Access

Regioselective Ru(ii)-catalyzed C–H alkenylation and annulation of indoles: a direct approach to fused lactone scaffolds

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Authors

JRJithender Rallabandi ISIndrajit ShownHindustan Institute of Technology and Science

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Implication

This research demonstrates regioselective lactone synthesis via Ru(II)-catalyzed alkenylation of indoles, indicating a novel pathway for scaffold creation.

Key Points

The study finds that Ru(II)-catalyzed reactions enable the direct synthesis of fused lactones from indole derivatives, enhancing synthesis efficiency.
Results show that regioselective reactions occur with indole-4-carboxylic acids, producing desired fused structures effectively.
Methods used include a unique alkenylation and annulation process that utilizes a weakly coordinating carboxylic acid as a directing group.
This novel approach supports the development of new chemical scaffolds, potentially benefiting drug discovery and material science.

Cite This Study

Rallabandi et al. (2025) studied this question.

synapsesocial.com/papers/68af63e9ad7bf08b1eae47c1 https://doi.org/10.1039/d5ra03671b

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Implication

This research demonstrates regioselective lactone synthesis via Ru(II)-catalyzed alkenylation of indoles, indicating a novel pathway for scaffold creation.

Regioselective Ru(ii)-catalyzed C–H alkenylation and annulation of indoles: a direct approach to fused lactone scaffolds

Discussion

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Implication

Key Points

Cite This Study

Regioselective Ru(ii)-catalyzed C–H alkenylation and annulation of indoles: a direct approach to fused lactone scaffolds

Discussion

Member takes

Implication

Key Points

Cite This Study

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