2-Pyridyl Sulfoxide Directed Pd(II)-Catalyzed Regioselective C2- Arylation/Alkenylation of Indoles

Kanchan Yadav; Ram Singh Jat; Ritesh Singh; Bhupendra Goswami; M. Bhanuchandra

doi:10.1039/d6ob00484a

January 1, 2025Organic & Biomolecular Chemistry

2-Pyridyl Sulfoxide Directed Pd(II)-Catalyzed Regioselective C2- Arylation/Alkenylation of Indoles

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Key Points

The aim is to explore a new Pd(II)-catalyzed method for regioselective modifications of indoles.
Utilized Pd(II) as a catalyst for reactions.
Employed 2-pyridyl sulfoxide as a directing group.
Conducted reactions with iodoarenes and both activated and unactivated alkenes.
Achieved regioselective C2-arylation and alkenylation of indoles.
Demonstrated effectiveness with various iodoarenes and alkenes.

Implication

Investigation shows regioselective C2-arylation and alkenylation in indoles, suggesting a new synthetic pathway.

Abstract

The present study reports a Pd(II)-catalysed regioselective C2-arylation and alkenylation of indoles using iodoarenes and activated/unactivated alkenes, respectively, directed by 2-pyridyl sulfoxide at the C3-position of indole for the first...

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Cite This Study

Yadav et al. (2025) studied this question.

synapsesocial.com/papers/69e47282010ef96374d8e8cb https://doi.org/10.1039/d6ob00484a

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2-Pyridyl Sulfoxide Directed Pd(II)-Catalyzed Regioselective C2- Arylation/Alkenylation of Indoles

Key Points

Implication

Abstract

Discussion

Cite This Study

2-Pyridyl Sulfoxide Directed Pd(II)-Catalyzed Regioselective C2- Arylation/Alkenylation of Indoles

Key Points

Implication

Abstract

Discussion

Cite This Study

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