This approach demonstrates good functional group compatibility, highlighting the effectiveness of Pd-catalyzed oxidative dehydrogenation and C2-selective arylation.
We report an efficient synthetic approach to 2-arylindoles from indolines via a one-step process involving Pd-catalyzed oxidative dehydrogenation and a sequential C2-regioselective Heck-type reaction. The mild reaction conditions, which utilize O2 as the sole oxidant, show a broad substrate scope and good functional group compatibility.
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Yang et al. (2025) studied this question.
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