What question did this study set out to answer?

To develop an efficient ruthenium(II)-catalyzed intermolecular cascade involving C–H activation and oxidative cyclization for synthesizing 2-arylindolines.

January 1, 2017Chemical Communications

Ruthenium(ii)-catalyzed intermolecular synthesis of 2-arylindolines through C–H activation/oxidative cyclization cascade

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Authors

MMManash Kumar MannaBankura University SBSamir Kumar BhuniaMidnapore Medical College and Hospital RJRanjan JanaIndian Institute of Chemical Biology

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Implication

Experimental study demonstrates ruthenium-catalyzed carboamination using unbiased styrenes, indicating an efficient cascade route to functionalized 2-arylindolines.

Key Points

To develop an efficient ruthenium(II)-catalyzed intermolecular cascade involving C–H activation and oxidative cyclization for synthesizing 2-arylindolines.
Coupled readily accessible protected anilines with unbiased vinyl arenes under ruthenium(II) catalysis.
Employed an interrupted Heck-type manifold guided by a pyrimidine directing group to steer ortho-metalation.
Successfully assembled the indoline nucleus using unbiased styrenes while avoiding β-hydride elimination pathways.
Confirmed a cascade mechanism involving pyrimidine-directed electrophilic ortho-metalation, alkene insertion, amine coordination, and reductive elimination.

Cite This Study

Manna et al. (2017) studied this question.

synapsesocial.com/papers/6a01fd10f58f6e6cfdd8d1b9 https://doi.org/10.1039/c7cc03053c

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Implication

Experimental study demonstrates ruthenium-catalyzed carboamination using unbiased styrenes, indicating an efficient cascade route to functionalized 2-arylindolines.

Ruthenium(ii)-catalyzed intermolecular synthesis of 2-arylindolines through C–H activation/oxidative cyclization cascade

Discussion

Member takes

Implication

Key Points

Cite This Study

Ruthenium(ii)-catalyzed intermolecular synthesis of 2-arylindolines through C–H activation/oxidative cyclization cascade

Discussion

Member takes

Implication

Key Points

Cite This Study

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