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January 1, 2025Chemical CommunicationsOpen Access

Ruthenium(ii)-catalyzed C-2 alkenylation of indole with olefins via a quinazolin-4(3H)-one directing group: a platform for selective fluorescent anion sensors

Rekha Thakur Vijay Luxami Kamaldeep Paul

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Key Points

The process enables C–H alkenylation of indole derivatives, enhancing the development of fluorescent sensors.
Using alkenes, the alkenylation reaction achieved significant selectivity with respect to various substrates.
This method utilizes a quinazolin-4(3H)-one directing group to facilitate the reaction.
The findings could support the design of selective fluorescent anion sensors for practical applications.

Implication

Ruthenium(II)-catalyzed alkenylation improves selectivity in indole derivatives, suggesting potential in fluorescent sensors.

Abstract

We report a ruthenium( ii )-catalyzed C–H alkenylation of 2-(1 H -indol-3-yl)quinazolin-4(3 H )-one with various alkenes.

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Cite This Study

Thakur et al. (2025) studied this question.

synapsesocial.com/papers/68af5407ad7bf08b1eadad0b https://doi.org/10.1039/d5cc00984g

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