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February 8, 2026Organic LettersOpen Access

Regioselective C2-Sulfonylation of Indoles and Pyrroles via SO 2 Insertions

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Authors

RBRekha BaiWCWan-Lin ChengCPChun-Yu Peng

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Overview

Molecular iodine-catalyzed C2-sulfonylation shows good yields in indoles and pyrroles, suggesting a sustainable method.

Key Points

  • To develop a new method for the regioselective C2-sulfonylation of indoles and pyrroles using sulfate sources.
  • Utilized molecular iodine as a catalyst in a three-component cascade reaction.
  • Combined indoles/pyrroles, anilines, and DABSO in reactions under mild conditions.
  • Generated arylsulfonyl radicals in situ from anilines and DABSO.
  • Achieved good to excellent yields for C2-sulfonylated products.
  • Successfully demonstrated a broad substrate diversity.
  • Confirmed the effectiveness of DABSO as a sulfone source.

Cite This Study

Bai et al. (2026) studied this question.

synapsesocial.com/papers/698827570fc35cd7a8845fbbhttps://doi.org/10.1021/acs.orglett.6c00146
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