Radical sulfonylation and cyclization produces pyrroloindoles and quinoline-diones, indicating a new synthetic route for organic compounds.
Radical sulfonylation/cyclization of 1-acryloyl-2-cyanoindoles/2-cyano-N-arylacrylamides with aryldiazonium tetrafluoroborates and Na2S2O5 has been developed for the synthesis of pyrrolo[1,2-a]indoles and quinoline-2,4-diones. Na2S2O5 serves as a dual-function reagent, acting as both a reducing agent and a sulfur dioxide surrogate for the generation of sulfonyl radicals, which underwent a cascade sequence, including radical addition to the C═C bonds, intramolecular cyclization, and hydrolysis to deliver the final products.
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Luo et al. (2026) studied this question.
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