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September 24, 2025

A Pilot Multiplex Salivary Transcriptomic Analysis to Understand the Sex-specific Effects of Maternal Opioid Use in Offspring

Tomoko Kaneko-Tarui Francesca Carasi-Schwartz Kiran Singh Kelsea R. Gildawie Fair M. Vassoler Elizabeth M. Byrnes Elizabeth Yen

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Key Points

Maternal opioid use alters reward and inflammatory pathways in neonates, affecting health outcomes.
Analysis revealed upregulated pathways in males and downregulated pathways in females, emphasizing sex-specific effects.
Pilot study utilized multiplex salivary transcriptomic analysis to examine 72 genes in opioid-exposed neonates.
Findings highlight the potential need for tailored interventions based on sex to address opioid-related impacts.

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Implication

Observational study assesses sex-specific molecular impacts of maternal opioid use on neonates, suggesting significant health implications.

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Cite This Study

Kaneko-Tarui et al. (2025) studied this question.

synapsesocial.com/papers/68d6cd68b1249cec298b3ad4 https://doi.org/10.21203/rs.3.rs-7418166/v1

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

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