Pd-Catalyzed Electrophile Cross-Coupling of Pyridylphosphonium Salts with Arylthianthrenium Salts to Access C4-Arylated Pyridines

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This is a Experimental Study study.

Chen Chen; Ziyi Wang; Xiao-Xu Zhang; Kui Wang; Bolin Zhu

doi:10.1039/d5cc05044h

January 1, 2025Chemical Communications

Pd-Catalyzed Electrophile Cross-Coupling of Pyridylphosphonium Salts with Arylthianthrenium Salts to Access C4-Arylated Pyridines

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Key Points

The reaction successfully produces C4-arylated pyridines, simplifying diverse synthesis routes.
Using mild conditions, it effectively couples pyridylphosphonium and arylthianthrenium salts for site-selectivity.
The methodology highlights efficient C–H/C–H cross-coupling that broadens available synthetic methods.
Palladium-catalyzed reactions like this provide significant implications for advancing organic synthesis.

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Implication

This research demonstrates a cross-coupling reaction using palladium, enabling C-H selectivity in pyridine synthesis.

Abstract

We reported a palladium-catalyzed electrophilic cross-coupling between pyridylphosphonium and arylthianthrenium salts that enables site-selective formal C–H/C–H cross-coupling of arenes with pyridines, providing C4-arylated pyridines under mild conditions. This methodology offers...

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Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d6cd68b1249cec298b3c0a https://doi.org/10.1039/d5cc05044h

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Pd-Catalyzed Electrophile Cross-Coupling of Pyridylphosphonium Salts with Arylthianthrenium Salts to Access C4-Arylated Pyridines

Key Points

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Implication

Abstract

Discussion

Cite This Study

Pd-Catalyzed Electrophile Cross-Coupling of Pyridylphosphonium Salts with Arylthianthrenium Salts to Access C4-Arylated Pyridines

Key Points

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Implication

Abstract

Discussion

Cite This Study

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