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September 23, 2025Synfacts

Multicomponent Palladium-Catalyzed Coupling–Amination–Acylation Reaction Yielding Piperidinones

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Key Points

The novel method yields piperidinones through a multicomponent reaction, improving synthetic efficiency.
Key findings include the effectiveness of palladium catalysis, showing significant yield with 4-pentenoic acid.
The innovative approach utilizes a coupling–amination–acylation reaction to streamline lactam production.
This new reaction pathway highlights potential for wider applications in organic synthesis, warranting further study.

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Implication

This approach demonstrates a novel method to synthesize piperidinones using multicomponent reaction and Pd catalysis, enhancing efficiency.

Abstract

Keywords multicomponent reaction - Pd catalysis - 4-pentenoic acid - lactams

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Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68d6d82e8b2b6861e4c3e0b6 https://doi.org/10.1055/a-2680-9414

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