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September 24, 2025European Journal of Gastroenterology & HepatologyOpen Access

Dissecting causal relationships between inflammatory factors, plasma metabolites, and nonalcoholic fatty liver disease: a mediating Mendelian randomization study

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Authors

DZDequan ZhongChina Coal Technology and Engineering Group Corp (China)SDShizhan DengChina Coal Technology and Engineering Group Corp (China)YDYonggan DongWenzhou Medical University

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Overview

Mendelian randomization identifies mediating roles of plasma metabolites in inflammatory factors and NAFLD, suggesting new intervention strategies.

Key Points

  • Mediation analysis reveals specific metabolites, like X-21471, mediate between inflammatory factors and NAFLD.
  • The study finds 11 inflammatory factors and 110 plasma metabolites significantly associated with NAFLD.
  • By employing Mendelian randomization, causal relationships were identified between inflammation and metabolic factors linked to NAFLD.
  • Findings suggest targeting TNFRSF9 and X-21471 may offer new preventive strategies for NAFLD in high-risk populations.

Cite This Study

Zhong et al. (2025) studied this question.

synapsesocial.com/papers/68d6d82e8b2b6861e4c3e240https://doi.org/10.1097/meg.0000000000003077
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