The study demonstrates advances in in situ forming implants for sustained drug release, highlighting potential advantages over preformed implants.
Introduction In situ forming implants (ISFIs) are long-acting drug delivery systems that solidify at the injection site, creating a depot for sustained drug release from days to months. Compared with preformed implants, ISFIs offer unique advantages, including easier and more convenient administration and simpler manufacturing. Among the different types, solvent-based ISFIs are the most extensively studied and developed formulations.
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Lozza et al. (2025) studied this question.
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