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September 24, 2025Open Access

The Association Between Inflammatory Indices and Mortality in Patients with Moderate-to-Severe Tricuspid Regurgitation

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Authors

JZJiayuan ZhangBeihang UniversityMXMengjie XieGeneral / Preventive / LipidsZZZiwei ZhouSun Yat-sen University

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Implication

Retrospective cohort study links systemic immune-inflammation index and neutrophil-to-lymphocyte ratio with mortality, suggesting improved risk stratification.

Key Points

  • An increase in log-transformed SII correlates with a 26% increased risk of mortality in moderate-to-severe TR.
  • NLR shows a stronger association with mortality, with a 57% increased risk per unit increase in log-transformed NLR.
  • The study followed 1,349 patients with moderate-to-severe TR over a median of 4.9 years, highlighting significant mortality outcomes.
  • Elevated inflammatory indices can enhance risk stratification for patients with moderate-to-severe TR, with implications for management decisions.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8ba8b2b6861e4c3f075https://doi.org/10.1101/2025.09.16.25335947
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating Novel Inflammatory Indices and Their Links to Mortality, Cancer, and Cardiovascular Disease: A 10‐Year Cohort Study2026
  2. 2Association between systemic immune-inflammation index(SII) and all-cause and cardiovascular mortality in heart failure patients: a single-center retrospective analysis2026 · 1 citations
  3. 3Associations between blood cell-based inflammatory indices and their changes and mortality in patients undergoing transcatheter aortic valve replacement: a retrospective investigation with prospective multicenter cohort validation study2025 · 4 citations
  4. 4The Clinical Value of Systemic Immune Inflammatory Index in Predicting the Prognosis of Patients with Bloodstream Infection2025 · 10 citations
  5. 5The Association Between Systemic Immune Inflammation Index and Intermediate-Term Mortality in Patients with Acute Coronary Syndromes2024 · 1 citations