Case report highlights intervention effects on generalized pustular psoriasis and epilepsy in a pediatric patient, suggesting complex genetic influences.
Methods We report a 10-year-old male pediatric patient with refractory Generalized Pustular Psoriasis (GPP), comorbid epilepsy, hyperactivity, hypoproteinaemia. The coexistence of IL36RN: c.115 + 6T > C homozygous mutation and c.227C > T(p.P76L) heterozygous variation may have worsened his disease phenotype.
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Wang et al. (2025) studied this question.
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