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This is a Quantitative Study study.

September 24, 2025HRB Open ResearchOpen Access

A protocol for assessing stability and invariance properties of two commonly used outcome measures in anxiolytic clinical trials

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Protocol assesses stability and invariance of anxiety measures in clinical trials, indicating the utility of network analysis methods.

Stability and invariance will determine the efficacy of anxiety treatment plans using network analysis.
Bootstrapping and permutation techniques will analyze the two key anxiety outcome measures in trials.
Network models will be evaluated for moderating factors like age and treatment type to ensure accuracy.
Findings could reshape clinical trial approaches, informing better treatment strategies if models prove stable.

Byrne et al. (2025) studied this question.

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