Cascade Cyclization of Thiolated Ene-ynes and Azodicarboxylates for Tetrahydroindole Synthesis

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September 23, 2025Synfacts

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Key Points

This process achieves the synthesis of tetrahydroindoles efficiently, utilizing a one-pot reaction method to streamline production.
The one-pot reaction resulted in notable yields of fused pyrroles and tetrahydroindoles, enhancing synthetic efficiency.
By employing azodicarboxylates with thiolated ene-ynes, the cascade reaction effectively facilitates complex molecular construction.
The findings highlight improvements in the synthesis of tetrahydroindoles, suggesting applicability in diverse chemical workflows.

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One-pot reaction yields tetrahydroindoles from ene-yne sulfides and azodicarboxylates, suggesting efficient synthesis methods.

Keywords one-pot reaction - tetrahydroindoles - fused pyrroles - cascade reaction - cyclization - ene-yne sulfides - azodicarboxylates

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