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This is a Experimental Study study.

September 24, 2025

A translational model for in vivo intestinal permeability assessment in pigs.

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Experimental analysis observed diet-induced effects on intestinal permeability in pigs, suggesting model utility for nutrition research.

Successful development of a translational model for assessing intestinal permeability in pigs, offering insights into dietary influences.
Indomethacin treatment caused a significant increase in intestinal permeability, with cumulative excretion of sucralose rising from 332.7 to 559.8 mg.
Assessment included urinary recovery of sucralose, along with evaluation of faecal biomarkers and intestinal health indicators.
Recommendations provided for optimizing intestinal permeability assessment protocols, indicating relevance for both pig and human studies.

Rymenant et al. (2025) studied this question.

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