Antimicrobial Activity of Naturally Occurring and Semi-Synthetic Chlorinated Compounds

Introduction/Objective: Antimicrobial resistance (AMR) has become a global controversial issue, making conventional treatments less effective. Hence, the design and development of new and efficient antimicrobial agents are on the researchers’ agenda to reduce death rates and health care costs. In this regard, chlorine-containing compounds have been the center of attention. This review highlights the antimicrobial potential of chlorine-containing natural and semi-synthetic compounds, aiming to identify versatile candidates effective against microorganisms. Methods: The literature was comprehensively surveyed using Google Scholar, Web of Science, Scopus, and PubMed, focusing on studies published since 2016, focusing on the antimicrobial properties of natural and semi-synthetic chlorinated compounds. Results: Natural chlorinated compounds have shown remarkable antimicrobial activity, generally more potent than their semi-synthetic counterparts. Discussion: The strong activity against resistant strains like MRSA underlines their therapeutic potential in addressing pressing clinical challenges. Nature-derived scaffolds serve as a promising foundation for the development of novel antimicrobial agents. Conclusion: Several naturally occurring compounds have proven more effective than their semisynthetic derivatives, making them attractive candidates for addressing the growing threat of AMR.