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This is a Quantitative Study study.

September 24, 2025Open Access

Epigenetic aging in a self-fertilizing vertebrate, the mangrove rivulus Kryptolebias marmoratus

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This research develops an epigenetic clock for DNA methylation in Kryptolebias marmoratus, indicating patterns in aging and biological function.

The study establishes a reliable epigenetic clock for aging in the self-fertilizing vertebrate Kryptolebias marmoratus, demonstrating the role of DNA methylation.
Using 90 brain tissue samples from individuals aged 60-1100 days, researchers achieved an R squared value greater than 0.96 and a mean absolute error of 28.7 days.
The investigation identifies key genes relevant to aging, including lamin-A and aryl hydrocarbon receptor, suggesting a connection to Alzheimer's disease and functional changes.
By proposing several methods to enhance classic epigenetic clock regression, findings highlight significant DNA methylation changes throughout the lifespan in isogenic individuals.

Bélik et al. (2025) studied this question.

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This research develops an epigenetic clock for DNA methylation in Kryptolebias marmoratus, indicating patterns in aging and biological function.