Normal Reference Range Values of Arterial Spin Labeling of Magnetic Resonance Imaging Brain Perfusion during Normal Maturation from Childhood through Adolescence to Adulthood

OBJECTIVE The aim of this study was to evaluate cerebral blood flow using arterial spin labeling magnetic resonance imaging in normal healthy subjects from childhood through adolescence to adulthood.METHODS A total of 38 normal, healthy subjects age between 8 and 32 were evaluated during the years 2018-2021 using arterial spin labeling magnetic resonance imaging.RESULTS The average region of interest (ROI) of all brain regions combined in all subjects was 37.05 ± 11.94/100 g per minute. The difference in average ROI in all regions in males and females was not statistically significant. The differences in average ROI in each of the brain regions by age group was not statistically significant. The average ROI of all brain regions combined and in each of the regions were not statistically significantly correlated with age.CONCLUSIONS During the transition from childhood through adolescence to adulthood, there is no correlation between age or gender and overall cerebral blood flow in all regions as measured by the arterial spin labeling (ASL) method.