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September 27, 2025Indian Journal of Medical and Paediatric OncologyOpen Access

Synchronous Dual Primary Malignancies of Lung and Colon: A Case Report with Review of Literature Emphasizing the Role of Molecular Profiling in Diagnostic Differentiation

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Authors

UMUdip MaheshwariDMDisha MorzariaKCKrushna Chaudhari

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Overview

Case report describes synchronous adenocarcinomas of the lung and colon, highlighting molecular profiling's role in diagnosis.

Key Points

  • Synchronous primary malignancies were found in a 75-year-old male, highlighting diagnostic challenges.
  • Both tumors revealed a shared KRAS mutation, indicating independent tumor origins via comprehensive evaluation.
  • Next-generation sequencing and immunohistochemistry confirmed the distinct genomic alterations for each adenocarcinoma.
  • A multidisciplinary approach is essential for managing synchronous malignant tumors, especially in elderly patients.

Cite This Study

Maheshwari et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3d4eebfec0fc52362e0https://doi.org/10.1055/s-0045-1811971
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