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September 27, 2025Open Access

Intravenous Thrombolysis for Acute Central Retinal Artery Occlusion: Protocol For a Systematic Review and Individual Participant Data Meta-Analysis of Randomized Controlled Trials

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Authors

BGBrian Mac GroryUniversity College DublinCPCécile PreterreCentre Hospitalier Universitaire de NantesPLPierre LebranchuÉcole Centrale de Nantes

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Overview

Systematic review assesses whether intravenous thrombolysis improves visual outcomes in adults with central retinal artery occlusion, indicating its potential effectiveness.

Key Points

  • Thrombolysis may improve visual outcomes, reporting primary endpoint as best corrected visual acuity (BCVA) ≥ 20/63.
  • Systematic review includes RCTs enrolling patients within 4.5 hours of symptoms, informing treatment guidelines.
  • Mixed logistic and linear regression models will analyze trial data, assessing risk of bias with Cochrane Tool for robust results.
  • Findings could support decision-making by healthcare professionals and guideline bodies regarding CRAO treatments.

Cite This Study

Grory et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3d4eebfec0fc523634fhttps://doi.org/10.1101/2025.09.24.25336565
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ABSTRACT NUMBER: ESOC2026A2225 EFFECTIVENESS AND SAFETY OF INTRAVENOUS THROMBOLYSIS FOR NON-ARTERITIC CENTRAL RETINAL ARTERY OCCLUSION: A GRADE-ASSESSED META-ANALYSIS2026
  2. 2Early Thrombolysis and Outcomes in Central Retinal Artery Occlusion: An Individual Participant Data Meta-Analysis2025
  3. 3Early Thrombolysis and Outcomes in Central Retinal Artery Occlusion: An Individual Participant Data Meta-Analysis2025 · 9 citations
  4. 4Analysis of the Therapeutic Effect of Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion2025
  5. 5Intravenous thrombolysis for acute central retinal artery occlusion: Protocol for a systematic review and individual participant data meta-analysis of randomized controlled trials2026 · 3 citations