Proving Thrombophilia in Symptoms of Hypersplenism

Our interest in proving thrombophilia in symptoms of hypersplenism was sparked by a common and, at first glance, innocent clinical symptom - heaviness or pain in the left lower abdomen, in patients with anemia caused by iron deficiency or vitamin deficiency B12. We aimed to investigate some aspects of hypersplenism. Our task was to pay attention to how some, insignificant at first glance, clinical symptoms could hide the pathogenesis of tomophilias. For the realization of this task, we examined 130 patients, using their subjective complaints, supplemented them with abdominal ultrasound and laboratory blood analysis (PCK - WBC count; Er; Thr (thrombopenia; erythropenia; leukopenia;-pancytopenia), morphology of erythrocytes, morphology of platelets. Biochemistry - bilirubin - total and direct, iron, VLDL, VLDL, ferritin, vitаmin B12, etc. Coagulation - bleeding time). In the course of the study, we found that more than two-thirds of the patients with the diagnosed disease (97 people) complained of this type of heaviness or pain, which appeared very often after physical, and in some cases even after nervous- mental strain. Often, precisely these symptoms are the reason, if the patient comes to a competent doctor, to do the right tests, to make the correct diagnosis and to start adequate treatment. In the specific setting, we found that with adequate application of the substitution therapy and reaching the laboratory parameters characterizing the recovery, the pain and severity subside. Such symptoms, however, should always provoke the difficult and often very unpleasant diagnosis of thrombophilias in terms of differential diagnosis.