Key result
Functional asplenia (HJB+) after splenectomy was associated with a shorter median time to first thrombotic event (316 vs 478 months; p=0.01) and more cumulative thrombotic events compared to HJB-.
Why the study?
Does functional asplenia after splenectomy increase the risk of thrombotic cardiovascular events?
Population
298 outpatients after splenectomy (177 [89.4%] due to trauma) and matched controls.
Comparison
Functional asplenia vs HJB- splenectomized patients and matched controls
Design
Case-control
Authors
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May heighten post-splenectomy thrombotic risk in functional asplenia; hypothesis-generating and requires prospective confirmation.
Case-Control (n=298)
Does functional asplenia after splenectomy increase the risk of thrombotic cardiovascular events?
p-value: p=0.01
Functional asplenia after splenectomy is associated with sustained inflammation, increased platelet activation, and a significantly higher risk of thrombotic cardiovascular events.
Gerges et al. (2017) conducted a case-control in Splenectomy (n=298). Functional asplenia (Howell-Jolly bodies positive) vs. Howell-Jolly bodies negative patients and matched controls was evaluated on Time to first thrombotic event (p=0.01). Functional asplenia (HJB+) after splenectomy was associated with a shorter median time to first thrombotic event (316 vs 478 months; p=0.01) and more cumulative thrombotic events compared to HJB-.
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