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This is a Experimental Study study.

September 27, 2025Cancer Research

Abstract B027: EZH2 and Menin inhibition induce neuronal differentiation and GD2 expression in neuroblastoma

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Analysis shows combined EZH2 and Menin inhibition improves GD2 expression in neuroblastoma, suggesting epigenetic therapy may enhance immunotherapy.

Combined inhibition of EZH2 and Menin increased GD2 expression significantly in neuroblastoma cells.
The research found that neuronal differentiation was induced through regulation of bivalent promoters after treatment.
This approach offers a potential therapeutic strategy to improve responses to anti-GD2 immunotherapy in resistant cases.
Sustained GD2 expression was observed for 30 days post-treatment cessation in an orthotopic neuroblastoma model.

Salhotra et al. (2025) studied this question.

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Analysis shows combined EZH2 and Menin inhibition improves GD2 expression in neuroblastoma, suggesting epigenetic therapy may enhance immunotherapy.