What type of study is this?

This is a In Vitro Study study (also classified as: Quantitative Study).

Anticancer Activity and Apoptosis Induction of Alkaloid Fraction of Kratom Leaves (Mitragyna speciosa) on Breast Cancer Cells: In Vitro and In Silico Studies

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In vitro and in silico analysis shows alkaloid fractions of kratom induce apoptosis and cytotoxicity in T47D breast cancer cells.

The alkaloid fraction of kratom leaves exhibits moderate cytotoxic activity with an IC50 of 96.23 µg/mL against T47D breast cancer cells.
Molecular docking identified polyneuridinealdehyde as having the greatest potential against estrogen receptors and yohimbine against Bcl-2 receptors.
The study utilizes both LC-MS/MS for alkaloid identification and the MTT assay method to assess cytotoxic effects on T47D cells.
Alkaloids in kratom leaves significantly promote apoptosis in T47D cells compared to untreated controls.

Priatna et al. (2025) studied this question.

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View Full Paper

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Authors

In vitro and in silico analysis shows alkaloid fractions of kratom induce apoptosis and cytotoxicity in T47D breast cancer cells.

The alkaloid fraction of kratom leaves exhibits moderate cytotoxic activity with an IC50 of 96.23 µg/mL against T47D breast cancer cells.
Molecular docking identified polyneuridinealdehyde as having the greatest potential against estrogen receptors and yohimbine against Bcl-2 receptors.
The study utilizes both LC-MS/MS for alkaloid identification and the MTT assay method to assess cytotoxic effects on T47D cells.
Alkaloids in kratom leaves significantly promote apoptosis in T47D cells compared to untreated controls.

Priatna et al. (2025) studied this question.

View Full Paper

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